Journal article
Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin
Abstract
OBJECTIVES: Increase in periostin (PN) was reported in clear cell renal cell carcinoma (ccRCC). But how PN contributes to ccRCC pathogenesis remains unclear. This research will investigate the underlying mechanism.
METHODS: The PN protein in 37 adjacent non-tumour kidney (ANK) tissues, their respective ccRCCs, 16 cases of metastasised ccRCC and xenograft tumours was analysed by immunohistochemistry. PN expression in ccRCC cells and NIH3T3 …
Authors
Bakhtyar N; Wong N; Kapoor A; Cutz J-C; Hill B; Ghert M; Tang D
Journal
European Journal of Cancer, Vol. 49, No. 16, pp. 3537–3546
Publisher
Elsevier
Publication Date
November 2013
DOI
10.1016/j.ejca.2013.06.032
ISSN
0959-8049
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAged, 80 and overAnimalsCarcinoma, Renal CellCell AdhesionCell Adhesion MoleculesCell Line, TumorCell ProliferationCoculture TechniquesEnzyme ActivationFemaleFibroblastsHEK293 CellsHumansKidney NeoplasmsMaleMiceMice, Inbred NODMice, SCIDMiddle AgedNIH 3T3 CellsNeoplasm TransplantationProto-Oncogene Proteins c-aktStromal CellsTransfectionUp-Regulation