Journal article
Efficacy and Safety of Recombinant Human Bone Morphogenetic Protein-2/Calcium Phosphate Matrix for Closed Tibial Diaphyseal Fracture
Abstract
BACKGROUND: Recombinant human bone morphogenetic protein-2 (rhBMP-2) applied on an absorbable collagen sponge improves open tibial fracture-healing as an adjunct to unreamed intramedullary nail fixation. We evaluated rhBMP-2 and a new, injectable calcium phosphate matrix (CPM) formulation in acute closed tibial diaphyseal fractures treated with reamed intramedullary nail fixation.
METHODS: Patients were randomized (1:2:2:1) to receive standard …
Authors
Lyon T; Scheele W; Bhandari M; Koval KJ; Sanchez EG; Christensen J; Valentin A; Huard F
Journal
Journal of Bone and Joint Surgery, Vol. 95, No. 23, pp. 2088–2096
Publisher
Wolters Kluwer
Publication Date
December 2013
DOI
10.2106/jbjs.l.01545
ISSN
0021-9355
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultBone Morphogenetic Protein 2Bone NailsCalcium PhosphatesDiaphysesDose-Response Relationship, DrugDouble-Blind MethodFeasibility StudiesFemaleFracture Fixation, IntramedullaryFracture HealingFractures, ClosedHumansInjections, IntralesionalMalePostoperative ComplicationsRecombinant ProteinsTibial FracturesTime FactorsTransforming Growth Factor beta