Journal article
ATM activation is accompanied with earlier stages of prostate tumorigenesis
Abstract
The ATM (ataxia telangiectasia mutated) kinase plays an essential role in maintaining genome integrity by coordinating cell cycle arrest, apoptosis, and DNA damage repair. Phosphorylation of ATM at serine 1981 (ATMpSer1981) by DNA damage activates ATM, which subsequently phosphorylates H2AX Ser139 (gammaH2AX), Chk2 Thr68 (Chk2pThr68), and p53 Ser15 (p53pSer15). To determine the role of the ATM pathway in prostate cancer tumorigenesis, we have …
Authors
Fan C; Quan R; Feng X; Gillis A; He L; Matsumoto ED; Salama S; Cutz J-C; Kapoor A; Tang D
Journal
Biochimica et Biophysica Acta, Vol. 1763, No. 10, pp. 1090–1097
Publisher
Elsevier
Publication Date
October 2006
DOI
10.1016/j.bbamcr.2006.08.026
ISSN
0006-3002
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAtaxia Telangiectasia Mutated ProteinsBiomarkers, TumorCarcinomaCell Cycle ProteinsCheckpoint Kinase 2DNA-Binding ProteinsHistonesHumansMaleMiddle AgedPhosphorylationProstateProstatic Intraepithelial NeoplasiaProstatic NeoplasmsProtein Serine-Threonine KinasesTumor Suppressor Protein p53Tumor Suppressor Proteins