Conference
Effects of genetic fusion of factor IX to albumin on in vivo clearance in mice and rabbits
Abstract
Individuals with haemophilia B require replacement therapy with recombinant or plasma-derived coagulation factor IX (fIX). More benefit per injected dose might be obtained if fIX clearance could be slowed. The contribution of overall size to fIX clearance was explored, using genetic fusion to albumin. Recombinant murine fIX (MIX), and three proteins with C-terminal epitope tags were expressed in HEK 293 cells: tagged MIX (MIXT), tagged mouse …
Authors
Sheffield WP; Mamdani A; Hortelano G; Gataiance S; Eltringham‐Smith L; Begbie ME; Leyva RA; Liaw PS; Ofosu FA
Volume
126
Pagination
pp. 565-573
Publisher
Wiley
Publication Date
August 2004
DOI
10.1111/j.1365-2141.2004.05106.x
Conference proceedings
British Journal of Haematology
Issue
4
ISSN
0007-1048