Journal article
Expression of the 1,25‐dihydroxyvitamin D3‐24‐hydroxylase gene in rat intestine: Response to calcium, vitamin D3 and calcitriol administration in vivo
Abstract
The 25(OH)D3/1,25(OH)2D3 24-hydroxylase (24-hydroxylase) displays an induction profile responsive to vitamin D (D) abundance and is hence only observed in normal extracellular Ca2+ concentrations. However, the participation of Ca2+ in the expression of the 24-hydroxylase gene in vivo is not known. The present studies investigate the role played by the circulating Ca2+ and the D3 and/or 1,25(OH)2D3 status on the 1,25(OH)2D3-mediated inducibility …
Authors
Lemay J; Demers C; Hendy GN; Delvin EE; Gascon‐Barré M
Journal
Journal of Bone and Mineral Research, Vol. 10, No. 8, pp. 1148–1157
Publisher
Oxford University Press (OUP)
Publication Date
August 1, 1995
DOI
10.1002/jbmr.5650100803
ISSN
0884-0431
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Analysis of VarianceAnimalsBlotting, NorthernCalcitriolCalciumCholecalciferolCytochrome P-450 Enzyme SystemDNA ProbesDown-RegulationEnzyme InductionFemaleGene Expression Regulation, EnzymologicIntestine, SmallMaleRNA, MessengerRatsRats, Sprague-DawleySteroid HydroxylasesVitamin D DeficiencyVitamin D3 24-Hydroxylase