Journal article
Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug‐metabolizing enzyme CYP3A4 in the human fetal intestine
Abstract
BACKGROUND AND AIMS: The human fetal jejunum has been shown to harbour the vitamin D3 (D3) nuclear receptor (VDRn) and to be responsive to calcitriol/1,25-dihydroxyvitamin D3[1,25(OH)2D3] through modulation of proliferation and differentiation processes. The aim of the study was to evaluate the presence as well as the effect of 1,25(OH)2D3 exposure on the expression levels of the three key D3-hydroxylase gene transcripts (25-hydroxylase, CYP27A;…
Authors
Theodoropoulos C; Demers C; Delvin E; Ménard D; Gascon‐Barré M
Journal
Clinical Endocrinology, Vol. 58, No. 4, pp. 489–499
Publisher
Wiley
Publication Date
April 2003
DOI
10.1046/j.1365-2265.2003.01743.x
ISSN
0300-0664
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
25-Hydroxyvitamin D3 1-alpha-HydroxylaseCalcitriolCholecalciferolCholestanetriol 26-MonooxygenaseColonCulture TechniquesCytochrome P-450 CYP3ACytochrome P-450 Enzyme SystemGene ExpressionGestational AgeHumansIntestinesJejunumKidneyLiverPolymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSteroid HydroxylasesVitamin D3 24-Hydroxylase