Journal article
14 day endoscopy study comparing risedronate and alendronate in postmenopausal women stratified by Helicobacter pylori status.
Abstract
OBJECTIVE: Bisphosphonates are effective treatment for osteoporosis but have been associated with gastrointestinal (GI) mucosal injury. This study compared the incidence of gastric ulcers after treatment with risedronate, a pyridinyl bisphosphonate, or alendronate, a primary amino bisphosphonate, in healthy postmenopausal women stratified by Helicobacter pylori status.
METHODS: Subjects were randomized to receive risedronate 5 mg (n = 318) or …
Authors
Thomson ABR; Marshall JK; Hunt RH; Provenza JM; Lanza FL; Royer MG; Li Z; Blank MA
Journal
The Journal of Rheumatology, Vol. 29, No. 9, pp. 1965–1974
Publication Date
September 2002
ISSN
0315-162X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAlendronateAnalysis of VarianceConfidence IntervalsDose-Response Relationship, DrugDrug Administration ScheduleEtidronic AcidFemaleFollow-Up StudiesGastric MucosaGastroscopyHelicobacter InfectionsHelicobacter pyloriHumansMiddle AgedOsteoporosis, PostmenopausalProbabilityReference ValuesRisedronic AcidRisk AssessmentSingle-Blind MethodStomach UlcerTreatment Outcome