Journal article
EGFR-PLCγ1 signaling mediates high glucose-induced PKCβ1-Akt activation and collagen I upregulation in mesangial cells
Abstract
Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We have recently shown that epidermal growth factor receptor (EGFR) transactivation mediates high glucose (HG)-induced collagen I upregulation through PI3K-PKCbeta1-Akt signaling in mesangial cells (MC). Phospholipase Cgamma1 (PLCgamma1) interacts with activated growth factor receptors and activates classic PKC isoforms. We thus studied its role in HG-induced collagen I …
Authors
Wu D; Peng F; Zhang B; Ingram AJ; Kelly DJ; Gilbert RE; Gao B; Kumar S; Krepinsky JC
Journal
American Journal of Physiology. Renal physiology, Vol. 297, No. 3, pp. f822–f834
Publisher
American Physiological Society
Publication Date
September 2009
DOI
10.1152/ajprenal.00054.2009
ISSN
0363-6127
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlood GlucoseCells, CulturedCollagen Type IDiabetes Mellitus, ExperimentalDiabetic NephropathiesEnzyme ActivationEnzyme InhibitorsErbB ReceptorsEstrenesFemaleMaleMesangial CellsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhospholipase C gammaPhosphorylationProtein Kinase CProtein Kinase C betaProto-Oncogene Proteins c-aktPyrrolidinonesQuinazolinesRNA InterferenceRatsRats, Sprague-DawleyTyrphostinsUp-Regulation