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Genome Wide Association Identifies Common Variants...
Journal article

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

Abstract

Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian …

Authors

Bolton JL; Hayward C; Direk N; Lewis JG; Hammond GL; Hill LA; Anderson A; Huffman J; Wilson JF; Campbell H

Journal

PLOS Genetics, Vol. 10, No. 7,

Publisher

Public Library of Science (PLoS)

DOI

10.1371/journal.pgen.1004474

ISSN

1553-7390