Journal article
Invariant NKT cells sustain specific B cell responses and memory
Abstract
Invariant natural killer T (iNKT) cells are innate-like lymphocytes recognizing CD1d-restricted glycolipid antigens, such as alpha-galactosylceramide (alphaGC). We assessed whether iNKT cells help B lymphocyte responses and found that mice immunized with proteins and alphaGC develop antibody titers 1-2 logs higher than those induced by proteins alone. Activation of iNKT cells enhances protection against infections such as influenza and elicits …
Authors
Galli G; Pittoni P; Tonti E; Malzone C; Uematsu Y; Tortoli M; Maione D; Volpini G; Finco O; Nuti S
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 10, pp. 3984–3989
Publisher
Proceedings of the National Academy of Sciences
Publication Date
March 6, 2007
DOI
10.1073/pnas.0700191104
ISSN
0027-8424