Journal article
Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene
Abstract
Humans with immune-compromised conditions such as SCID are unable to control infection caused by normally nonpathogenic intracellular pathogens such as Mycobacterium bovis bacillus Calmette-Guérin. We found that SCID beige mice lacking both lymphocytes and NK cells had functionally normal lung macrophages and yet a selectively impaired response of type 1 cytokines IFN-gamma and IL-12, but not TNF-alpha, during M. bovis bacillus Calmette-Guérin …
Authors
Xing Z; Zganiacz A; Wang J; Sharma SK
Journal
The Journal of Immunology, Vol. 167, No. 1, pp. 375–383
Publisher
Oxford University Press (OUP)
Publication Date
July 1, 2001
DOI
10.4049/jimmunol.167.1.375
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAdjuvants, ImmunologicAdministration, IntranasalAnimalsCytokinesGene Transfer TechniquesGenetic VectorsImmunity, InnateImmunization ScheduleImmunophenotypingInterferon-gammaInterleukin-12LungMacrophage ActivationMacrophages, AlveolarMiceMice, Inbred BALB CMice, Inbred C57BLMice, SCIDMycobacterium InfectionsNitric OxidePhagocytosisTransgenesTumor Necrosis Factor-alpha