Journal article
Mucosal Luminal Manipulation of T Cell Geography Switches on Protective Efficacy by Otherwise Ineffective Parenteral Genetic Immunization
Abstract
Genetic immunization holds great promise for future vaccination against mucosal infectious diseases. However, parenteral genetic immunization is ineffective in control of mucosal intracellular infections, and the underlying mechanisms have remained unclear. By using a model of parenteral i.m. genetic immunization and pulmonary tuberculosis (TB), we have investigated the mechanisms that determine the failure and success of parenteral genetic …
Authors
Santosuosso M; McCormick S; Roediger E; Zhang X; Zganiacz A; Lichty BD; Xing Z
Journal
The Journal of Immunology, Vol. 178, No. 4, pp. 2387–2395
Publisher
Oxford University Press (OUP)
Publication Date
February 15, 2007
DOI
10.4049/jimmunol.178.4.2387
ISSN
0022-1767