Journal article
Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin‐10 on organ allograft and tumour rejection
Abstract
Mouse bone marrow-derived myeloid dendritic cells (DC) propagated in granulocyte-macrophage colony-stimulating factor and transforming growth factor-beta1 (TGF-beta1) (so-called 'TGF-beta DC') are phenotypically immature, and prolong allograft survival. Interleukin-10 (IL-10) has been shown to inhibit the maturation of DC by down-regulating surface major histocompatibility complex (MHC) class II, co-stimulatory and adhesion molecule expression. …
Authors
Lee W; Qiani S; Wan Y; Li W; Xing Z; Gauldie J; Fung JJ; Thomson AW; Lu L
Journal
Immunology, Vol. 101, No. 2, pp. 233–241
Publisher
Wiley
Publication Date
October 2000
DOI
10.1046/j.1365-2567.2000.00096.x
ISSN
0019-2805
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenoviruses, HumanAnimalsCytotoxicity, ImmunologicDendritic CellsGenetic VectorsGraft RejectionHeart TransplantationIsoantibodiesKiller Cells, NaturalLymphocyte Culture Test, MixedMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMyeloid CellsNeoplasm TransplantationNeoplasms, ExperimentalSpleenTransforming Growth Factor betaTumor Cells, Cultured