Journal article
Chronic performance of polyurethane catheters covalently coated with ATH complex: A rabbit jugular vein model
Abstract
Covalent complexes of antithrombin (AT) and heparin (ATH) have superb anticoagulant activity towards thrombin and factor Xa. Stability of polyurethane central venous catheters covalently modified with radiolabeled ATH was studied using a roller pump with saline or protease P-5147. Saline wash removed loosely bound ATH molecules to decrease graft density from 26 to 12 pmol/cm2. However, only slightly more ATH was removed by strong protease (from …
Authors
Klement P; Du YJ; Berry LR; Tressel P; Chan AKC
Journal
Biomaterials, Vol. 27, No. 29, pp. 5107–5117
Publisher
Elsevier
Publication Date
October 2006
DOI
10.1016/j.biomaterials.2006.05.005
ISSN
0142-9612