Journal article
Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle
Abstract
We investigated the effects of five different isoprostanes (8-iso PGE1, 8-iso PGE2, 8-iso PGF1alpha, 8-iso PGF2alpha and 8-iso PGF2beta) on vasomotor tone in human and porcine bronchial arterial tissues. In the human bronchial arteries, 8-iso PGE2 and 8-iso PGF2alpha evoked powerful constrictions (magnitudes several fold greater than the responses to high millimolar KCl) with negative log concentration causing 50% excitation (EC50) values of …
Authors
Tazzeo T; Miller J; Janssen LJ
Journal
British Journal of Pharmacology, Vol. 140, No. 4, pp. 759–763
Publisher
Wiley
Publication Date
October 2003
DOI
10.1038/sj.bjp.0705482
ISSN
0007-1188
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AlprostadilAmidesAnimalsBronchial ArteriesDinoprostDinoprostoneDioxanesDose-Response Relationship, DrugF2-IsoprostanesGenisteinHumansIsoprostanesMuscle, Smooth, VascularProstaglandins EProstaglandins F, SyntheticPyridinesReceptors, Thromboxane A2, Prostaglandin H2Signal TransductionSwineVasoconstrictionVasoconstrictor Agents