Journal article
Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells
Abstract
OBJECTIVE: Natural killer (NK) cells are lymphocytes well suited for adoptive immunotherapy. Attempts with adoptive NK cell immunotherapy against ovarian cancer have proven unsuccessful, with the main limitations including failure to expand and diminished effector function. We investigated if incubation of NK cells with interleukin (IL)-12, IL-15, and IL-18 for 16h could produce cytokine-induced memory-like (CIML) NK cells capable of enhanced …
Authors
Uppendahl LD; Felices M; Bendzick L; Ryan C; Kodal B; Hinderlie P; Boylan KLM; Skubitz APN; Miller JS; Geller MA
Journal
Gynecologic Oncology, Vol. 153, No. 1, pp. 149–157
Publisher
Elsevier
Publication Date
4 2019
DOI
10.1016/j.ygyno.2019.01.006
ISSN
0090-8258
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsCarcinoma, Ovarian EpithelialCell Line, TumorCell ProliferationCytokine-Induced Killer CellsFemaleHumansImmunologic MemoryImmunotherapy, AdoptiveInterferon-gammaInterleukin-12Interleukin-15Interleukin-18InterleukinsKiller Cells, NaturalLymphocyte ActivationMiceRecombinant ProteinsTumor Necrosis Factor-alphaXenograft Model Antitumor Assays