Journal article
Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study
Abstract
Late-life depression (LLD) is often accompanied by medical comorbidities such as psychiatric disorders and cardiovascular diseases, posing challenges to antidepressant treatment. Recent studies highlighted significant associations between treatment-resistant depression (TRD) and polygenic risk score (PRS) for attention deficit hyperactivity disorder (ADHD) in adults as well as a negative association between antidepressant symptom improvement …
Authors
Elsheikh SSM; Marshe VS; Men X; Islam F; Gonçalves VF; Paré G; Felsky D; Kennedy JL; Mulsant BH; Reynolds CF
Journal
The Pharmacogenomics Journal, Vol. 24, No. 6,
Publisher
Springer Nature
Publication Date
December 2024
DOI
10.1038/s41397-024-00351-0
ISSN
1470-269X