Journal article
The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans
Abstract
The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for protecting dopaminergic neurons and functioning in various other tissues. Previously, we showed that Caenorhabditis elegans manf-1 null mutants exhibit defects such as increased endoplasmic reticulum (ER) stress, dopaminergic neurodegeneration, and abnormal protein aggregation. These findings suggest an essential role for MANF in cellular processes. However, …
Authors
Taylor SKB; Hartman JH; Gupta BP
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 121, No. 43,
Publisher
Proceedings of the National Academy of Sciences
Publication Date
October 22, 2024
DOI
10.1073/pnas.2403906121
ISSN
0027-8424