Journal article
Impact of Angiotensin Converting Enzyme Inhibitors on Pathologic Complete Response With Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer
Abstract
INTRODUCTION: The renin-angiotensin system (RAS) has been demonstrated to modulate cell proliferation, desmoplasia, angiogenesis and immunosuppression. We examined the association of RAS inhibitors (RASi)-namely angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB)-with neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) preceding radical cystectomy (RC).
PATIENTS AND METHODS: We …
Authors
Skelton WP; Masur J; Thomas J; Fallah P; Jain RK; Ravi P; Mantia C; McGregor BA; Nuzzo PV; Adib E
Journal
Clinical Genitourinary Cancer, Vol. 22, No. 5,
Publisher
Elsevier
Publication Date
October 2024
DOI
10.1016/j.clgc.2024.102143
ISSN
1558-7673
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
HumansMaleFemaleUrinary Bladder NeoplasmsAngiotensin-Converting Enzyme InhibitorsNeoadjuvant TherapyAgedMiddle AgedRetrospective StudiesTreatment OutcomeCystectomyAngiotensin Receptor AntagonistsNeoplasm InvasivenessAged, 80 and overAdultAntineoplastic Combined Chemotherapy ProtocolsPathologic Complete Response