Journal article
Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial
Abstract
BACKGROUND: Higher levels of inflammatory biomarkers are associated with an increased risk of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery (MINS). Colchicine is an anti-inflammatory drug that might reduce the incidence of these complications.
METHODS: COP-AF was a randomised trial conducted at 45 sites in 11 countries. Patients aged 55 years or older and undergoing major non-cardiac thoracic surgery were …
Authors
Conen D; Wang MK; Popova E; Chan MTV; Landoni G; Cata JP; Reimer C; McLean SR; Srinathan SK; Reyes JCT
Journal
The Lancet, Vol. 402, No. 10413, pp. 1627–1635
Publisher
Elsevier
Publication Date
11 2023
DOI
10.1016/s0140-6736(23)01689-6
ISSN
0140-6736