Journal article
Molecular Sieving with PEGylated Dendron-Protein Conjugates
Abstract
A series of generation 3-5 dendrons based on a bis(2,2-hydroxymethylpropionic acid) (bis-MPA) scaffold bearing three respective lengths of linear poly(ethylene glycol) at their periphery and a dibenzocyclooctyne unit at their core was prepared. These dendrons were appended to the surface of azide-decorated α-chymotrypsin (α-CT) via strain-promoted azide-alkyne cycloaddition to yield a library of dendron-protein conjugates. These conjugates were …
Authors
Deng B; Burns E; McNelles SA; Sun J; Ortega J; Adronov A
Journal
Bioconjugate Chemistry, Vol. 34, No. 8, pp. 1467–1476
Publisher
American Chemical Society (ACS)
Publication Date
August 16, 2023
DOI
10.1021/acs.bioconjchem.3c00237
ISSN
1043-1802