Journal article
Association of Neighborhood Deprivation and Depressive Symptoms With Epigenetic Age Acceleration: Evidence From the Canadian Longitudinal Study on Aging
Abstract
BACKGROUND: Neighborhood deprivation and depression have been linked to epigenetic age acceleration. The next-generation epigenetic clocks including the DNA methylation (DNAm) GrimAge, and PhenoAge have incorporated clinical biomarkers of physiological dysregulation by selecting cytosine-phosphate-guanine sites that are associated with risk factors for disease, and have shown improved accuracy in predicting morbidity and time-to-mortality …
Authors
Joshi D; van Lenthe FJ; Huisman M; Sund ER; Krokstad S; Avendano M; Raina P
Journal
The Journals of Gerontology Series A, Vol. 79, No. 2,
Publisher
Oxford University Press (OUP)
Publication Date
February 1, 2024
DOI
10.1093/gerona/glad118
ISSN
1079-5006