Insulinlike Growth Factor I in Combination With Insulinlike Growth Factor Binding Protein 3 Affects the Hepatic Acute Phase Response and Hepatic Morphology in Thermally Injured Rats

OBJECTIVE: To modulate the hepatic acute phase response after a thermal injury by the administration of insulin-like growth factor I (IGF-I) in combination with its principal binding protein 3 (IGFBP-3). SUMMARY BACKGROUND DATA: The hepatic acute phase response is a cascade of events initiated to restore homeostasis after trauma; however, a prolonged response contributes to multiorgan failure, hypermetabolism, complications, and death. Although …