Journal article
Xin‐deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality
Abstract
AIM: Xin is an F-actin-binding protein expressed during development of cardiac and skeletal muscle. We used Xin-/- mice to determine the impact of Xin deficiency on different aspects of skeletal muscle health, including functionality and regeneration.
METHODS: Xin-/- skeletal muscles and their satellite cell (SC) population were investigated for the presence of myopathic changes by a series of histological and immunofluorescent stains on …
Authors
Al-Sajee D; Nissar AA; Coleman SK; Rebalka IA; Chiang A; Wathra R; van der Ven PFM; Orfanos Z; Hawke TJ
Journal
Acta Physiologica, Vol. 214, No. 2, pp. 248–260
Publisher
Wiley
Publication Date
June 2015
DOI
10.1111/apha.12455
ISSN
1748-1708