Journal article
THE EFFECTS OF DNASE I AND LOW-MOLECULAR-WEIGHT HEPARIN IN A MURINE MODEL OF POLYMICROBIAL ABDOMINAL SEPSIS
Abstract
ABSTRACT: Introduction: Cell-free DNA (CFDNA) has emerged as a prognostic biomarker in patients with sepsis. Circulating CFDNA is hypothesized to be associated with histones in the form of nucleosomes. In vitro, DNA activates coagulation and inhibits fibrinolysis, whereas histones activate platelets and are cytotoxic to endothelial cells. Previous studies have targeted CFDNA or histones in animal models of sepsis using DNase I or heparins, …
Authors
Medeiros SK; Sharma N; Dwivedi D; Cani E; Zhou J; Dwivedi N; Sohrabipour S; Liaw PC
Journal
Shock, Vol. 59, No. 4, pp. 666–672
Publisher
Wolters Kluwer
Publication Date
April 2023
DOI
10.1097/shk.0000000000002095
ISSN
1073-2322