Exercise training and low dose radiation protect skeletal muscle from high dose radiation

Radiation is a lethal, carcinogenic, mutagenic and oxidative stress‐inducing stimulus at high doses (HDR). In low doses (LDR), however, radiation is a hormetic stimulus that protects against oxidative stress by activating cellular defence mechanisms. Exercise training (EX) activates many of the same defence systems, suggesting that EX may be a potent radioprotectant. To examine whether EX could protect skeletal muscle against HDR, we divided …