Journal article
The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure
Abstract
BACKGROUND: The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains controversial. We studied the effect of digoxin on mortality and hospitalization in a randomized, double-blind clinical trial.
METHODS: In the main trial, patients with a left ventricular ejection fraction of 0.45 or less were randomly assigned to digoxin (3397 patients) or placebo (3403 patients) in addition to diuretics …
Authors
Group TDI
Journal
The New England Journal of Medicine, Vol. 336, No. 8, pp. 525–533
Publisher
Massachusetts Medical Society
Publication Date
February 20, 1997
DOI
10.1056/nejm199702203360801
ISSN
0028-4793