Journal article
Neurotrophic factors and Alzheimer’s disease: are we focusing on the wrong molecule?
Abstract
Brain derived neurotrophic factor (BDNF) promotes cholinergic neuron function and survival. In Alzheimer’s disease, BDNF mRNA and protein are decreased in basal forebrain cholinergic neuron target tissues such as cortex and hippocampus. Using RT-PCR, we demonstrate that BDNF is synthesized in basal forebrain, supplying cholinergic neurons with a local as well as a target-derived source of this factor. BDNF mRNA levels are decreased 50% in …
Authors
Fahnestock M; Garzon D; Holsinger RMD; Michalski B
Journal
Journal of Neural Transmission. Supplementa, Vol. 62, No. 62, pp. 241–252
Publisher
Springer Nature
Publication Date
2002
DOI
10.1007/978-3-7091-6139-5_22
ISSN
0303-6995