Journal article
A transgenic mouse line harboring a smooth muscle alpha-actin promoter polyomavirus middle T antigen transgene develops an epithelial hyperplasia in the rectum and distal stomach.
Abstract
BACKGROUND: Transgenic mice are the product of the microinjection of foreign DNA directly into the pronuclei of a one-cell embryo. The foreign DNA can cause insertional inactivation or activation of the flanking genetic locus.
EXPERIMENTAL DESIGN: We isolated five lines of transgenic mice harboring the chicken alpha-actin vascular smooth muscle enhancer/promoter linked to the polyomavirus middle T antigen using a standard microinjection …
Authors
Moghal N; Bonyadi S; Hassell JA; Alpert L; Chalifour LE
Journal
Laboratory Investigation, Vol. 72, No. 3, pp. 291–299
Publication Date
March 1995
ISSN
0023-6837
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ActinsAnimalsAntigens, Polyomavirus TransformingBase SequenceCell Transformation, NeoplasticCloning, MolecularFemaleGastric MucosaHyperplasiaInfertility, FemaleIntestinal MucosaMaleMiceMice, Mutant StrainsMice, TransgenicMolecular Sequence DataMuscle, SmoothPolymerase Chain ReactionPromoter Regions, GeneticRectum