Journal article
CD133+ brain tumor-initiating cells are dependent on STAT3 signaling to drive medulloblastoma recurrence
Abstract
Medulloblastoma (MB), the most common malignant paediatric brain tumor, is currently treated using a combination of surgery, craniospinal radiotherapy and chemotherapy. Owing to MB stem cells (MBSCs), a subset of MB patients remains untreatable despite standard therapy. CD133 is used to identify MBSCs although its functional role in tumorigenesis has yet to be determined. In this work, we showed enrichment of CD133 in Group 3 MB is associated …
Authors
Garg N; Bakhshinyan D; Venugopal C; Mahendram S; Rosa DA; Vijayakumar T; Manoranjan B; Hallett R; McFarlane N; Delaney KH
Journal
Oncogene, Vol. 36, No. 5, pp. 606–617
Publisher
Springer Nature
Publication Date
February 2017
DOI
10.1038/onc.2016.235
ISSN
0950-9232