Journal article
A Human Protein Interaction Network Shows Conservation of Aging Processes between Human and Invertebrate Species
Abstract
We have mapped a protein interaction network of human homologs of proteins that modify longevity in invertebrate species. This network is derived from a proteome-scale human protein interaction Core Network generated through unbiased high-throughput yeast two-hybrid searches. The longevity network is composed of 175 human homologs of proteins known to confer increased longevity through loss of function in yeast, nematode, or fly, and 2,163 …
Authors
Bell R; Hubbard A; Chettier R; Chen D; Miller JP; Kapahi P; Tarnopolsky M; Sahasrabuhde S; Melov S; Hughes RE
Journal
PLOS Genetics, Vol. 5, No. 3,
Publisher
Public Library of Science (PLoS)
Publication Date
March 2009
DOI
10.1371/journal.pgen.1000414
ISSN
1553-7390