Journal article
Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
Abstract
Background:We examined the potential of metformin (MET) to enhance non-small cell lung cancer (NSCLC) responses to ionising radiation (IR).Methods:Human NSCLC cells, mouse embryonic fibroblasts from wild-type and AMP-activated kinase (AMPK) α1/2-subunit−/− embryos (AMPKα1/2−/−-MEFs) and NSCLC tumours grafted into Balb/c-nude mice were treated with IR and MET and subjected to proliferation, clonogenic, immunoblotting, cell cycle and apoptosis …
Authors
Storozhuk Y; Hopmans SN; Sanli T; Barron C; Tsiani E; Cutz J-C; Pond G; Wright J; Singh G; Tsakiridis T
Journal
British Journal of Cancer, Vol. 108, No. 10, pp. 2021–2032
Publisher
Springer Nature
Publication Date
May 2013
DOI
10.1038/bjc.2013.187
ISSN
0007-0920
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenylate KinaseAnimalsAtaxia Telangiectasia Mutated ProteinsCarcinoma, Non-Small-Cell LungCell Cycle ProteinsCell ProliferationCells, CulturedDNA-Binding ProteinsDown-RegulationEmbryo, MammalianHumansLung NeoplasmsMetforminMiceMice, Inbred BALB CMice, KnockoutMice, NudeProtein Serine-Threonine KinasesRadiation-Sensitizing AgentsTumor Suppressor ProteinsXenograft Model Antitumor Assays