Journal article
Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins
Abstract
The proapoptotic BCL-2 homology (BH3)-only endoplasmic reticulum (ER)-resident protein BCL-2 interacting killer (BIK) positively regulates mitochondrial outer membrane permeabilization, the point of no return in apoptosis. It is generally accepted that BIK functions at a distance from mitochondria by binding and sequestering antiapoptotic proteins at the ER, thereby promoting ER calcium release. Although BIK is predominantly localized to the …
Authors
Osterlund EJ; Hirmiz N; Nguyen D; Pemberton JM; Fang Q; Andrews DW
Journal
Journal of Biological Chemistry, Vol. 299, No. 2,
Publisher
Elsevier
Publication Date
February 2023
DOI
10.1016/j.jbc.2022.102863
ISSN
0021-9258