Journal article
Brain-reactive antibodies and behavior of autoimmune MRL-lpr mice
Abstract
The hypothesis that brain-reactive autoantibodies (BRA) impair behavior was examined in MRL-lpr mice, which develop spontaneous autoimmune disease. Circulating BRA were measured as in vitro serum reactivity to Neuro-2A neuroblastoma cell line, and behavioral competence was assessed in activity monitors, open field, beam walking, and Morris water maze task. Mice with BRA in serum (BRA positive) exhibited slower spontaneous locomotion in a novel …
Authors
Šakić B; Szechtman H; Denburg S; Carbotte R; Denburg JA
Journal
Physiology & Behavior, Vol. 54, No. 5, pp. 1025–1029
Publisher
Elsevier
Publication Date
November 1993
DOI
10.1016/0031-9384(93)90319-b
ISSN
0031-9384