Journal article
Myostatin is associated with age‐related human muscle stem cell dysfunction
Abstract
Human aging is accompanied by a progressive loss of muscle mass (sarcopenia). We tested the hypothesis that older males (OMs, 70±4 yr, n=9) would have a blunted myogenic response to a physiological stimulus compared to younger controls (21±3 yr, n=9). Subjects completed an acute bout of intense unilateral muscle loading. Young healthy males matched for body mass and activity level served as the control group. Muscle biopsies and blood were …
Authors
McKay BR; Ogborn DI; Bellamy LM; Tarnopolsky MA; Parise G
Journal
The FASEB Journal, Vol. 26, No. 6, pp. 2509–2521
Publisher
Wiley
Publication Date
June 2012
DOI
10.1096/fj.11-198663
ISSN
0892-6638