Journal article
Modulation of radiation-induced strand break repair by cisplatin in mammalian cells
Abstract
PURPOSE: To investigate the repair of ionizing radiation-induced DNA lesions in human skin fibroblasts in the presence of cisplatin-DNA adducts and to determine the persistence of DNA repair inhibition by cisplatin.
MATERIALS AND METHODS: Normal human fibroblasts (AG 1522) treated with cisplatin were exposed to 4 Gy 60Co gamma-radiation and assayed for repair of radiation-induced damage under growth-permissive conditions. DNA damage was …
Authors
Dolling JA; Boreham DR; Brown DL; Mitchel RE; Raaphorst GP
Journal
International Journal of Radiation Biology, Vol. 74, No. 1, pp. 61–69
Publisher
Taylor & Francis
Publication Date
January 1998
DOI
10.1080/095530098141735
ISSN
0955-3002