Journal article
Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study
Abstract
BACKGROUND: Whole breast irradiation (WBI) after conservative surgery for ductal carcinoma in situ (DCIS) reduces local recurrence. We investigated whether a tumour bed boost after WBI improved outcomes, and examined radiation dose fractionation sensitivity for non-low-risk DCIS.
METHODS: The study was an international, randomised, unmasked, phase 3 trial involving 136 participating centres of six clinical trials organisations in 11 countries …
Authors
Chua BH; Link EK; Kunkler IH; Whelan TJ; Westenberg AH; Gruber G; Bryant G; Ahern V; Purohit K; Graham PH
Journal
The Lancet, Vol. 400, No. 10350, pp. 431–440
Publisher
Elsevier
Publication Date
August 2022
DOI
10.1016/s0140-6736(22)01246-6
ISSN
0140-6736