Journal article
The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells
Abstract
The lysine methyltransferase Smyd1 with its characteristic catalytic SET-domain is highly enriched in the embryonic heart and skeletal muscles, participating in cardiomyogenesis, sarcomere assembly and chromatin remodeling. Recently, significant Smyd1 levels were discovered in endothelial cells (ECs) that responded to inflammatory cytokines. Based on these biochemical properties, we hypothesized that Smyd1 is involved in inflammation-triggered …
Authors
Shamloul A; Steinemann G; Roos K; Liem CH; Bernd J; Braun T; Zakrzewicz A; Berkholz J
Journal
Cells, Vol. 10, No. 12,
Publisher
MDPI
DOI
10.3390/cells10123515
ISSN
2073-4409
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
DNA MethylationDNA-Binding ProteinsEndothelial CellsEpigenesis, GeneticGene Expression Regulation, DevelopmentalHuman Umbilical Vein Endothelial CellsHumansInflammationInterleukin-6LipopolysaccharidesMuscle ProteinsNF-kappa BPromoter Regions, GeneticRNA, Small InterferingSignal TransductionTranscription Factors