Journal article
Iron in airway macrophages and infective exacerbations of chronic obstructive pulmonary disease
Abstract
BackgroundExcess pulmonary iron has been implicated in the pathogenesis of lung disease, including asthma and COPD. An association between higher iron content in sputum macrophages and infective exacerbations of COPD has previously been demonstrated.ObjectivesTo assess the mechanisms of pulmonary macrophage iron sequestration, test the effect of macrophage iron-loading on cellular immune function, and prospectively determine if sputum …
Authors
Ho T; Nichols M; Nair G; Radford K; Kjarsgaard M; Huang C; Bhalla A; Lavigne N; Mukherjee M; Surette M
Journal
Respiratory Research, Vol. 23, No. 1,
Publisher
Springer Nature
Publication Date
12 2022
DOI
10.1186/s12931-022-01929-7
ISSN
1465-9921