Journal article
Genome-wide host methylation profiling of anal and cervical carcinoma
Abstract
HPV infection results in changes in host gene methylation which, in turn, are thought to contribute to the neoplastic progression of HPV-associated cancers. The objective of this study was to identify joint and disease-specific genome-wide methylation changes in anal and cervical cancer as well as changes in high-grade pre-neoplastic lesions. Formalin-fixed paraffin-embedded (FFPE) anal tissues (n = 143; 99% HPV+) and fresh frozen cervical …
Authors
Siegel EM; Ajidahun A; Berglund A; Guerrero W; Eschrich S; Putney RM; Magliocco A; Riggs B; Winter K; Simko JP
Journal
PLOS ONE, Vol. 16, No. 12,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0260857
ISSN
1932-6203
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAnus NeoplasmsBiomarkers, TumorCarcinoma, Squamous CellChemoradiotherapyClinical Trials, Phase III as TopicDNA MethylationFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticGenome, HumanHumansMaleMiddle AgedPrognosisRandomized Controlled Trials as TopicSurvival RateUterine Cervical NeoplasmsYoung Adult