Journal article
Coronary artery wall shear stress is associated with endothelial dysfunction and expansive arterial remodelling in patients with coronary artery disease.
Abstract
AIMS: To investigate in vivo relationships between segmental wall shear stress (WSS), endothelium-dependent vasoreactivity and arterial remodelling.
METHODS AND RESULTS: Twenty-four patients with minor angiographic coronary arterial disease (≤30% stenosis severity) underwent intracoronary (IC) salbutamol provocation during intravascular ultrasound (IVUS)-upon-Doppler guidewire imaging. Macrovascular response (change in segmental lumen volume …
Authors
Puri R; Leong DP; Nicholls SJ; Liew GYL; Nelson AJ; Carbone A; Copus B; Wong DT; Beltrame JF; Worthley SG
Journal
EuroIntervention, Vol. 10, No. 12, pp. 1440–1448
Publisher
Europa Digital & Publishing
Publication Date
4 2015
DOI
10.4244/eijv10i12a249
ISSN
1774-024X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adrenergic beta-2 Receptor AgonistsAlbuterolCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsEndothelium, VascularEnzyme InhibitorsFemaleHumansMaleMiddle AgedSeverity of Illness IndexShear StrengthUltrasonography, DopplerUltrasonography, InterventionalVascular RemodelingVasodilationomega-N-Methylarginine