Journal article
Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro
Abstract
OBJECTIVE: This study was designed to investigate the effect of Panax notoginseng saponin (PNS) on platelet adhesion to injured endothelial cells (ECs) and platelet activation induced by injured ECs, and to explore its underlying mechanisms.
METHODS: Human umbilical vein endothelial cells (HUVECs) pretreated with aspirin (ASA,15μg/mL) or PNS (160μg/mL), or neither, were exposed to oxidized low-density lipoprotein (ox-LDL,80mg/L) for 16h. …
Authors
Wang M-M; Xue M; Xu Y-G; Miao Y; Kou N; Yang L; Zhang Y; Shi D-Z
Journal
Thrombosis Research, Vol. 141, , pp. 146–152
Publisher
Elsevier
Publication Date
5 2016
DOI
10.1016/j.thromres.2016.03.022
ISSN
0049-3848