Journal article
Synthesis and Preclinical Evaluation of [18F]SiFA-PSMA Inhibitors in a Prostate Cancer Model
Abstract
Positron emission tomography (PET) imaging of prostate-specific membrane antigen (PSMA) with gallium-68 (68Ga) and fluorine-18 (18F) radiotracers has aroused tremendous interest over the past few years. The use of organosilicon-[18F]fluoride acceptors (SiFA) conjugated to urea-based peptidomimetic PSMA inhibitors provides a "kit-like" multidose synthesis technology. Nine novel 18F-labeled SiFA-bearing PSMA inhibitors with different linker …
Authors
Bailey JJ; Wuest M; Wagner M; Bhardwaj A; Wängler C; Wängler B; Valliant JF; Schirrmacher R; Wuest F
Journal
Journal of Medicinal Chemistry, Vol. 64, No. 21, pp. 15671–15689
Publisher
American Chemical Society (ACS)
Publication Date
November 11, 2021
DOI
10.1021/acs.jmedchem.1c00812
ISSN
0022-2623