Journal article
Micro-chemical synthesis of molecular probes on an electronic microfluidic device
Abstract
We have developed an all-electronic digital microfluidic device for microscale chemical synthesis in organic solvents, operated by electrowetting-on-dielectric (EWOD). As an example of the principles, we demonstrate the multistep synthesis of [(18)F]FDG, the most common radiotracer for positron emission tomography (PET), with high and reliable radio-fluorination efficiency of [(18)F]FTAG (88 ± 7%, n = 11) and quantitative hydrolysis to …
Authors
Keng PY; Chen S; Ding H; Sadeghi S; Shah GJ; Dooraghi A; Phelps ME; Satyamurthy N; Chatziioannou AF; Kim C-JC
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 3, pp. 690–695
Publisher
Proceedings of the National Academy of Sciences
Publication Date
January 17, 2012
DOI
10.1073/pnas.1117566109
ISSN
0027-8424
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsChromatography, Thin LayerElectronicsElectrowettingFluorine RadioisotopesFluorodeoxyglucose F18HalogenationHumansLymphomaMiceMice, SCIDMicrochemistryMicrofluidic Analytical TechniquesMolecular ProbesPositron-Emission TomographyQuality ControlTissue DistributionTomography, X-Ray ComputedXenograft Model Antitumor Assays