Journal article
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
Abstract
Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A central function of mitochondria is the synthesis of ATP by oxidative phosphorylation, known as mitochondrial bioenergetics. Mitochondria maintain oxidative phosphorylation by creating a membrane potential gradient that is generated by the electron transport chain to drive the synthesis of …
Authors
Momcilovic M; Jones A; Bailey ST; Waldmann CM; Li R; Lee JT; Abdelhady G; Gomez A; Holloway T; Schmid E
Journal
Nature, Vol. 575, No. 7782, pp. 380–384
Publisher
Springer Nature
Publication Date
November 14, 2019
DOI
10.1038/s41586-019-1715-0
ISSN
0028-0836