Journal article
Alterations in skeletal muscle repair in young adults with type 1 diabetes mellitus
Abstract
Though preclinical models of type 1 diabetes (T1D) exhibit impaired muscle regeneration, this has yet to be investigated in humans with T1D. Here, we investigated the impact of damaging exercise (eccentric quadriceps contractions) in 18 physically active young adults with and without T1D. Pre- and postexercise (48 h and 96 h), the participants provided blood samples, vastus lateralis biopsies, and performed maximal voluntary quadriceps …
Authors
Dial AG; Grafham GK; Monaco CMF; Voth J; Brandt L; Tarnopolsky MA; Hawke TJ
Journal
American Journal of Physiology - Cell Physiology, Vol. 321, No. 5, pp. c876–c883
Publisher
American Physiological Society
Publication Date
November 1, 2021
DOI
10.1152/ajpcell.00322.2021
ISSN
0363-6143
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultBiomarkersCase-Control StudiesCell ProliferationCreatine KinaseDiabetes Mellitus, Type 1Extracellular MatrixFemaleGene Expression RegulationHumansMaleMicrovascular DensityMuscle ContractionMuscle StrengthMuscular DiseasesQuadriceps MuscleRecovery of FunctionRegenerationSatellite Cells, Skeletal MuscleTime FactorsTranscriptomeYoung Adult