Journal article
Intravenous Administration of Stabilized Antisense Lipid Particles (SALP) Leads to Activation and Expansion of Liver Natural Killer Cells
Abstract
Stabilized antisense lipid particles (SALP) have been developed for the systemic delivery of oligonucleotides. The impact of intravenous SALP administration was measured with respect to activation of natural killer (NK) and NK1.1+ T (NKT) cells in the livers of immunocompetent mice. Treatment with a SALP containing a highly mitogenic oligonucleotide (INX-6295) generated an increase in NK cytolytic activity and cell number within the liver but …
Authors
Bramson JL; Bodner CA; Johnson J; Semple S; Hope MJ
Journal
Nucleic Acid Therapeutics, Vol. 10, No. 3, pp. 217–224
Publisher
Mary Ann Liebert
Publication Date
6 2000
DOI
10.1089/oli.1.2000.10.217
ISSN
2159-3337