Journal article
The CD8+ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-Term Immunity
Abstract
We have previously reported that the CD8+ T cell response elicited by recombinant adenovirus vaccination displayed a delayed contraction in the spleen. In our current study, we demonstrate that this unusual kinetic is a general phenomenon observed in multiple tissues. Phenotypic analysis of transgene-specific CD8+ T cells present 30 days postimmunization with recombinant adenovirus revealed a population with evidence of partial exhaustion, …
Authors
Yang T-C; Millar J; Groves T; Grinshtein N; Parsons R; Takenaka S; Wan Y; Bramson JL
Journal
The Journal of Immunology, Vol. 176, No. 1, pp. 200–210
Publisher
Oxford University Press (OUP)
Publication Date
January 1, 2006
DOI
10.4049/jimmunol.176.1.200
ISSN
0022-1767