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Mesenchymal Stromal Cells Expressing ErbB-2/neu...
Journal article

Mesenchymal Stromal Cells Expressing ErbB-2/neu Elicit Protective Antibreast Tumor Immunity In vivo, Which Is Paradoxically Suppressed by IFN-γ and Tumor Necrosis Factor-α Priming

Abstract

It is unknown whether mesenchymal stromal cells (MSC) can regulate immune responses targeting tumor autoantigens of low immunogenicity. We tested here whether immunization with MSC could break immune tolerance towards the ErbB-2/HER-2/neu tumor antigen and the effects of priming with IFN-γ and tumor necrosis factor-α (TNF-α) on this process. BALB/c- and C57BL/6-derived MSC were lentivirally transduced to express a kinase-inactive rat neu mutant …

Authors

Romieu-Mourez R; François M; Abate A; Boivin M-N; Birman E; Bailey D; Bramson JL; Forner K; Young Y-K; Medin JA

Journal

Cancer Research, Vol. 70, No. 20, pp. 7742–7747

Publisher

American Association for Cancer Research (AACR)

Publication Date

October 15, 2010

DOI

10.1158/0008-5472.can-10-0296

ISSN

0008-5472