Journal article
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice
Abstract
Ligands for the NKG2D receptor are overexpressed on tumors, making them interesting immunotherapy targets. To assess the tumoricidal properties of T cells directed to attack NKG2D ligands, we engineered murine T cells with two distinct NKG2D-based chimeric antigen receptors (CARs): (i) a fusion between the NKG2D receptor and the CD3ζ chain and (ii) a conventional second-generation CAR, where the extracellular domain of NKG2D was fused to CD28 …
Authors
VanSeggelen H; Hammill JA; Dvorkin-Gheva A; Tantalo DG; Kwiecien JM; Denisova GF; Rabinovich B; Wan Y; Bramson JL
Journal
Molecular Therapy, Vol. 23, No. 10, pp. 1600–1610
Publisher
Elsevier
Publication Date
10 2015
DOI
10.1038/mt.2015.119
ISSN
1525-0016
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Adoptive TransferAnimalsCell Line, TumorCell MembraneCyclophosphamideCytokinesCytotoxicity, ImmunologicDisease Models, AnimalFemaleGene ExpressionGenetic VectorsImmunotherapy, AdoptiveLigandsMiceNK Cell Lectin-Like Receptor Subfamily KNeoplasmsPneumoniaReceptors, Antigen, T-CellReceptors, ImmunologicRecombinant Fusion ProteinsRetroviridaeT-LymphocytesTransplantation Conditioning